PUBLICATIONS

  • Lin ZC, Hwang TL, Huang TH, Tahara K, Trousil J, Fang JY. Monovalent antibody-conjugated lipid-polymer nanohybrids for active targeting to desmoglein 3 of keratinocytes to attenuate psoriasiform inflammation. Theranostics. 11: 4567-4584. 2021. https://www.thno.org/v11p4567.htm
  • Yamazoe E, Fang J-Y, Tahara K. Oral mucus-penetrating PEGylated liposomes to improve drug absorption: Differences in the interaction mechanisms of a mucoadhesive liposome. Int J Pharm. 593: 120148. 2021. https://doi.org/10.1016/j.ijpharm.2020.120148
  • Tahara K. Pharmaceutical formulation and manufacturing using particle/powder technology for personalized medicines. Adv Powder Technol. 31: 387-392. 2020. https://doi.org/10.1016/j.apt.2019.10.031
  • Takeuchi Y, Murase Y, Tahara K, Takeuchi H. Impact of surface roughness of pre-treated punches and powder properties on prevention of sticking during pharmaceutical tableting. J Drug Deliv Sci Technol. 60: 101999. 2020. https://doi.org/10.1016/j.jddst.2020.101999
  • Takeuchi Y, Ikeda N, Tahara K, Takeuchi H. Mechanical characteristics of orally disintegrating films: Comparison of folding endurance and tensile properties. Int J Pharm. 589: 119876. 2020. https://doi.org/10.1016/j.ijpharm.2020.119876
  • Takeuchi Y, Nishimatsu T, Tahara K, Takeuchi H. Novel use of insoluble particles as disintegration enhancers for orally disintegrating films. J Drug Deliv Sci Technol. 54: 101310. 2019. https://doi.org/10.1016/j.jddst.2019.101310
  • Okubo Y, Takeuchi Y, Mizuno H, Matoba H, Tahara K, Takeuchi H. Statistical analyses for the preparation of taste-masking granules using a pH-dependent polymer. J Drug Deliv Sci Technol. 53: 101124. 2019. https://doi.org/10.1016/j.jddst.2019.101124
  • Naganuma M, Tahara K, Hasegawa S, Fukuda A, Sasaoka S, Hatahira H, Motooka Y, Nakao S, Mukai R, Hirade K, Yoshimura T, Kato T, Takeuchi H, Nakamura M. Adverse event profiles of solvent-based and nanoparticle albumin-bound paclitaxel formulations using the Food and Drug Administration Adverse Event Reporting System. SAGE Open Medicine. 7: 2050312119836011. 2019. https://doi.org/10.1177%2F2050312119836011
  • Takeuchi Y, Kawamoto M, Tahara K, Takeuchi H. Design of a new disintegration test system for the evaluation of orally disintegrating films. Int J Pharm. 553: 281-289. 2018. https://doi.org/10.1016/j.ijpharm.2018.10.049
  • Oba T, Tahara K, Kato Y, Sonoda R, Kawashima Y, Takeuchi H. Development of a simple and practical method for estimating the liquid absorption of pharmaceutical porous materials using a capillary rise technique. Adv Powder Technol. 29: 3210-3219. 2018. https://doi.org/10.1016/j.apt.2018.08.027
  • Zhang P, Weeranoppanant N, Thomas DA, Tahara K, Stelzer T, Russell MG, O’Mahony M, Myerson AS, Lin H, Kelly LP. Advanced Continuous Flow Platform for On‐Demand Pharmaceutical Manufacturing. Chem Eur J. 24: 2776-2784. 2018. https://doi.org/10.1002/chem.201706004
  • Takeuchi Y, Umemura K, Tahara K, Takeuchi H. Formulation design of hydroxypropyl cellulose films for use as orally disintegrating dosage forms. J Drug Deliv Sci Technol. 46: 93-100. 2018
  • Takeuchi Y, Tomita T, Kuroda J, Kageyu A, Yonekura C, Hiramura Y, Tahara K, Takeuchi H. Characterization of mannitol granules and powder: A comparative study using two flowability testers. Int J Pharm. 2018. https://doi.org/10.1016/j.jddst.2018.05.002
  • Tahara K, Kono Y, Myerson AS, Takeuchi H. Development of Continuous Spherical Crystallization to Prepare Fenofibrate Agglomerates with Impurity Complexation Using Mixed-Suspension, Mixed-Product Removal Crystallizer. Crystal Growth & Design. 18: 6448-6454. 2018. https://doi.org/10.1021/acs.cgd.8b00426
  • Tahara K, Kobayashi M, Yoshida S, Onodera R, Inoue N, Takeuchi H. Effects of cationic liposomes with stearylamine against virus infection. Int J Pharm. 543: 311-317. 2018. https://doi.org/10.1016/j.ijpharm.2018.04.001
  • Osamura T, Takeuchi Y, Onodera R, Kitamura M, Takahashi Y, Tahara K, Takeuchi H. Formulation design of granules prepared by wet granulation method using a multi-functional single-punch tablet press to avoid tableting failures. Asisa J Pharm Sci. 13: 113-119. 2018. https://doi.org/10.1016/j.ajps.2017.08.002
  • Alalaiwe A, Hung C-F, Leu Y-L, Tahara K, Chen H-H, Hu K-Y, Fang J-Y. The active compounds derived from Psoralea corylifolia for photochemotherapy against psoriasis-like lesions: The relationship between structure and percutaneous absorption. Eur J Pharm Sci. 124: 114-126. 2018. https://doi.org/10.1016/j.ejps.2018.08.031
  • Takeuchi Y, Usui R, Ikezaki H, Tahara K, Takeuchi H. An advanced technique using an electronic taste-sensing system to evaluate the bitterness of orally disintegrating films and the evaluation of model films. Int J Pharm. 531: 179-190. 2017. https://doi.org/10.1016/j.ijpharm.2017.07.073
  • Takeuchi Y, Usui R, Ikezaki H, Tahara K, Takeuchi H. Characterization of orally disintegrating films: A feasibility study using an electronic taste sensor and a flow-through cell. J Drug Deliv Sci Technol. 39: 104-112. 2017. https://doi.org/10.1016/j.jddst.2017.03.010
  • Tahara K, Nishio M, Takeuchi H. Evaluation of liposomal behavior in the gastrointestinal tract after oral administration using real-time in vivo imaging. Drug Dev Ind Pharm. 44: 608-614. 2017. https://doi.org/10.1080/03639045.2017.1405972
  • Tahara K, Karasawa K, Onodera R, Takeuchi H. Feasibility of drug delivery to the eye’s posterior segment by topical instillation of PLGA nanoparticles. Asian J Pharm Sci. 12: 394-399. 2017. https://doi.org/10.1016/j.ajps.2017.03.002
  • Shimazawa M, Inoue Y, Masuda T, Onodera R, Tahara K, Shimizu Y, Mibe Y, Tsuruma K, Takeuchi H, Hara H. Topical Diclofenac-Loaded Liposomes Ameliorate Laser-Induced Choroidal Neovascularization in Mice and Non-Human Primates. Curr Neurovasc Res. 14: 46-52. 2017. https://doi.org/10.2174/1567202614666161104115440
  • Osamura T, Takeuchi Y, Onodera R, Kitamura M, Takahashi Y, Tahara K, Takeuchi H. Prediction of effects of punch shapes on tableting failure by using a multi-functional single-punch tablet press. Asian J Pharm Sci. 12:412-417. 2017. https://doi.org/10.1016/j.ajps.2017.05.001
  • Kakino Y, Hishikawa Y, Onodera R, Tahara K, Takeuchi H. Gelation Factors of Pectin for Development of a Powder Form of Gel, Dry Jelly, as a Novel Dosage Form. Chem Pharm Bull. 65: 1035-1044. 2017. https://doi.org/10.1248/cpb.c17-00447
  • Fukuda A, Tahara K, Hane Y, Matsui T, Sasaoka S, Hatahira H, Motooka Y, Hasegawa S, Naganuma M, Abe J, Nakao S, Takeuchi H, Nakamura M. Comparison of the adverse event profiles of conventional and liposomal formulations of doxorubicin using the FDA adverse event reporting system. PLoS One. 12: e0185654. 2017. https://doi.org/10.1371/journal.pone.0185654
  • Taketani Y, Usui T, Toyono T, Shima N, Yokoo S, Kimakura M, Yamagami S, Ohno S, Onodera R, Tahara K, Takeuchi H, Kuroda M. Topical Use of Angiopoietin-like Protein 2 RNAi-loaded Lipid Nanoparticles Suppresses Corneal Neovascularization. Mol Ther Nucleic Acids. 5: e292. 2016. https://doi.org/10.1038/mtna.2016.1
  • Tahara K, Tomida H, Ito Y, Tachikawa S, Onodera R, Tanaka H, Tozuka Y, Takeuchi H. Pulmonary liposomal formulations encapsulated procaterol hydrochloride by a remote loading method achieve sustained release and extended pharmacological effects. Int J Pharm. 505: 139-146. 2016. https://doi.org/10.1016/j.ijpharm.2016.03.031
  • Tahara K, Nishikawa M, Matsui K, Hisazumi K, Onodera R, Tozuka Y, Takeuchi H. In Vitro and In Vivo Characterization of Drug Nanoparticles Prepared Using PureNano Continuous Crystallizer to Improve the Bioavailability of Poorly Water Soluble Drugs. Pharm Res. 33: 2259-2268. 2016. https://doi.org/10.1007/s11095-016-1964-7
  • Tahara K, Hashimoto W, Takeuchi H. Inhalation Properties and Stability of Nebulized Naked siRNA Solution for Pulmonary Therapy. Chem Pharm Bull. 64: 63-67. 2016. https://doi.org/10.1248/cpb.c15-00615
  • Osamura T, Takeuchi Y, Onodera R, Kitamura M, Takahashi Y, Tahara K, Takeuchi H. Characterization of tableting properties measured with a multi-functional compaction instrument for several pharmaceutical excipients and actual tablet formulations. Int J Pharm. 510: 195-202. 2016. https://doi.org/10.1016/j.ijpharm.2016.05.024
  • Hishikawa Y, Kakino Y, Tsukamoto H, Tahara K, Onodera R, Takeuchi H. Control of Drug Diffusion Behavior of Xanthan and Locust Bean Gum Gel by Agar Gel. Chem Pharm Bull. 64: 1450-1457. 2016. https://doi.org/10.1248/cpb.c16-00135
  • Tanimura S, Tahara K, Takeuchi H. Spray-dried composite particles of erythritol and porous silica for orally disintegrating tablets prepared by direct tableting. Powder Technol. 286: 444-450. 2015. https://doi.org/10.1016/j.powtec.2015.08.011
  • Tahara K, O’Mahony M, Myerson AS. Continuous Spherical Crystallization of Albuterol Sulfate with Solvent Recycle System. Cryst Growth Des. 15: 5149-5156. 2015. https://doi.org/10.1021/acs.cgd.5b01159
  • Suzuki T, Nishii N, Takashima S, Matsubara T, Iwasawa A, Takeuchi H, Tahara K, Hachisu T, Kitagawa H. Ligand-binding characteristics of feline insulin-binding immunoglobulin G. J Vet Med Sci. 77: 1379-1383. 2015.https://doi.org/10.1292/jvms.15-0131
  • Ohnishi N, Tanaka S, Tahara K, Takeuchi H. Characterization of insulin-loaded liposome using column-switching HPLC. Int J Pharm. 479: 302-305. 2015.https://doi.org/10.1016/j.ijpharm.2014.12.056
  • Nakamura M, Umetsu R, Abe J, Matsui T, Ueda N, Kato Y, Sasaoka S, Tahara K, Takeuchi H, Kinosada Y. Analysis of the time-to-onset of osteonecrosis of jaw with bisphosphonate treatment using the data from a spontaneous reporting system of adverse drug events. J Pharm Health Care Sci. doi: 10.1186/s40780-015-0035-2. 2015. https://doi.org/10.1186/s40780-015-0035-2
  • Ohnishi N, Tomida H, Ito Y, Tahara K, Takeuchi H. Characterization of a doxorubicin liposome formulation by a novel in vitro release test methodology using column-switching high-performance liquid chromatography. Chem Pharm Bull. 62: 538-544. 2014. https://doi.org/10.1248/cpb.c14-00009
  • Murata M, Tahara K, Takeuchi H. Real-time in vivo imaging of surface-modified liposomes to evaluate their behavior after pulmonary administration. Eur J Pharm Biopharm. 86: 115-119. 2014. https://doi.org/10.1016/j.ejpb.2013.09.006
  • Chankhampan C, Manosroi J, Yamamoto H, Tahara K, Manosroi W, Kawashima Y, Manosroi A. Chemical stability enhancement and cytotoxicity reduction of papain loaded in PLGA nanospheres. J Exp Nanosci. 9: 138-151. 2014. https://doi.org/10.1080/17458080.2011.636385
  • Ying L, Tahara K, Takeuchi H. Drug delivery to the ocular posterior segment using lipid emulsion via eye drop administration: Effect of emulsion formulations and surface modification. Int J Pharm. 453: 329-335. 2013. https://doi.org/10.1016/j.ijpharm.2013.06.024
  • Tsukamoto T, Hironaka K, Fujisawa T, Yamaguchi D, Tahara K, Tozuka Y, Takeuchi H. Preparation ofbromfenac-loaded liposomesmodified with chitosan for ophthalmic drug delivery and evaluation of physicochemical properties and drug release profile. Asian J Pharm Sci. 8: 110-119. 2013.https://doi.org/10.1016/j.ajps.2013.07.013
  • Tozuka Y, Imono M, Uchiyama H, Tahara K, Tazawa S, Araki Y, Takeuchi H. Dry powder formulation with α-glycosyltransferase-treated stevia for the effective absorption of hydrophobic bioactive compounds in crude drugs. Powder Technol. 240: 2-6. 2013. https://doi.org/10.1016/j.powtec.2012.07.014
  • Tahara K, Fujimoto S, Fujii F, Tozuka Y, Jin T, Takeuchi H. Quantum Dot-Loaded Liposomes to Evaluate the Behavior of Drug Carriers after Oral Administration. J Pharm. Article ID 848275. 2013. https://doi.org/10.1155/2013/848275
  • Sasaki H, Karasawa K, Hironaka K, Tahara K, Tozuka Y, Takeuchi H. Retinal drug delivery using eyedrop preparations of poly-l-lysine-modified liposomes. Eur J Pharm Biopharm. 83: 364-369. 2013. https://doi.org/10.1016/j.ejpb.2012.10.014
  • Ozawa T, Yokoyama M, Hosono T, Nagato T, Tahara K, Takeuchi H. A novel approach to monitor coating amount by short-wavelength near-infrared spectroscopy using a tracer with a long-chain hydrocarbyl group. Int J Pharm. 458: 9-14. 2013. https://doi.org/10.1016/j.ijpharm.2013.10.015
  • Nagahara A, Mitani A, Fukuda M, Yamamoto H, Tahara K, Morita I, Ting CC, Watanabe T, Fujimura T, Osawa K, Sato S, Takahashi S, Iwamura Y, Kuroyanagi T, Kawashima Y, Noguchi T. Antimicrobial photodynamic therapy using a diode laser with a potential new photosensitizer, indocyanine green-loaded nanospheres, may be effective for the clearance of Porphyromonas gingivalis. J Periodontal Res. 48: 591-599. 2013. https://doi.org/10.1111/jre.12042
  • Murata M, Yonamine T, Tanaka S, Tahara K, Tozuka Y, Takeuchi H. Surface modification of liposomes using polymer-wheat germ agglutinin conjugates to improve the absorption of peptide drugs by pulmonary administration. J Pharm Sci. 102: 1281-1289. 2013. https://doi.org/10.1002/jps.23463
  • Katsuno E, Tahara K, Takeuchi Y, Takeuchi H. Orally disintegrating tablets prepared by a co-processed mixture of micronized crospovidone and mannitol using a ball mill to improve compactibility and tablet stability. Powder Technol. 241: 60-66. 2013. https://doi.org/10.1016/j.powtec.2013.03.008
  • Murata M, Nakano K, Tahara K, Tozuka Y, Takeuchi H. Pulmonary delivery of elcatonin using surface-modified liposomes to improve systemic absorption: Polyvinyl alcohol with a hydrophobic anchor and chitosan oligosaccharide as effective surface modifiers. Eur J Pharm Biopharm. 80: 340-346. 2012. https://doi.org/10.1016/j.ejpb.2011.10.011
  • Fujisawa T, Miyai H, Hironaka K, Tsukamoto T, Tahara K, Tozuka Y, Ito M, Takeuchi H. Liposomal diclofenac eye drop formulations targeting the retina: Formulation stability improvement using surface modification of liposomes. Int J Pharm. 436: 564-567. 2012. https://doi.org/10.1016/j.ijpharm.2012.07.024
  • Tahara K, Tadokoro S, Kawashima Y, Hirashima N. Endocytosis-like uptake of surface-modified drug nanocarriers into giant unilamellar vesicles. Langmuir. 28: 7114-7118. 2012. https://doi.org/10.1021/la300902z
  • Tahara K, Tadokoro S, Yamamoto H, Kawashima Y, Hirashima N. The suppression of IgE-mediated histamine release from mast cells following exocytic exclusion of biodegradable polymeric nanoparticles. Biomaterials. 33: 343-351. 2012. https://doi.org/10.1016/j.biomaterials.2011.09.043
  • Yamamoto H, Tahara K, Kawashima Y. Nanomedical system for nucleic acid drugs created with the biodegradable nanoparticle platform. J Microencapsul. 29: 54-62. 2012. https://doi.org/10.3109/02652048.2011.629745
  • Tahara K, Samura S, Tsuji K, Yamamoto H, Tsukada Y, Bando Y, Tsujimoto H, Morishita R, Kawashima Y. Oral nuclear factor-κB decoy oligonucleotides delivery system with chitosan modified poly(d,l-lactide-co-glycolide) nanospheres for inflammatory bowel disease. Biomaterials. 32: 870-878. 2011. https://doi.org/10.1016/j.biomaterials.2010.09.034
  • Tahara K, Sakai T, Yamamoto H, Takeuchi H, Hirashima N, Kawashima Y. Improvements in transfection efficiency with chitosan modified poly(DL-lactide-co-glycolide) nanospheres prepared by the emulsion solvent diffusion method, for gene delivery. Chem Pharm Bull. 59: 298-301. 2011.https://doi.org/10.1248/cpb.59.298
  • Tahara K, Miyazaki Y, Kawashima Y, Kreuter J, Yamamoto H. Brain targeting with surface-modified poly(d,l-lactic-co-glycolic acid) nanoparticles delivered via carotid artery administration. Eur J Pharm Biopharm. 77: 84-88. 2011. https://doi.org/10.1016/j.ejpb.2010.11.002
  • Tahara K, Kato Y, Yamamoto H, Kreuter J, Kawashima Y. Intracellular drug delivery using polysorbate 80-modified poly(D,L-lactide-co-glycolide) nanospheres to glioblastoma cells. J Microencapsul. 28: 29-36. 2011. https://doi.org/10.3109/02652048.2010.522258
  • Tahara K, Yamamoto H, Kawashima Y. Cellular uptake mechanisms and intracellular distributions of polysorbate 80-modified poly (d, l-lactide-co-glycolide) nanospheres for gene delivery. Eur J Pharm Biopharm. 75: 218-224. 2010. https://doi.org/10.1016/j.ejpb.2010.03.013
  • Tahara K, Furukawa S, Yamamoto H, Kawashima Y. Hybrid-modified poly(D,L-lactide-co-glycolide) nanospheres for a novel cellular drug delivery system. Int J Pharm. 392: 311-313. 2010. https://doi.org/10.1016/j.ijpharm.2010.03.042
  • Tahara K, Yamamoto H, Hirashima N, Kawashima Y. Chitosan-modified poly(D,L-lactide-co-glycolide) nanospheres for improving siRNA delivery and gene-silencing effects. Eur J Pharm Biopharm. 74: 421-426. 2010. https://doi.org/10.1016/j.ejpb.2009.12.007
  • Tahara K, Sakai T, Yamamoto H, Takeuchi H, Hirashima N, Kawashima Y. Improved cellular uptake of chitosan-modified PLGA nanospheres by A549 cells. Int J Pharm. 382: 198-204. 2009. https://doi.org/10.1016/j.ijpharm.2009.07.023
  • Tahara K, Sakai T, Yamamoto H, Takeuchi H, Kawashima Y. Establishing chitosan coated PLGA nanosphere platform loaded with wide variety of nucleic acid by complexation with cationic compound for gene delivery. Int J Pharm. 354: 210-216. 2008. https://doi.org/10.1016/j.ijpharm.2007.11.002

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